My Multiple Sclerosis

I did a blood test which came out very good. I am stopping the anticoagulant “Inohep” injection and starting anti-thrombotic Salospir (100mg) for three months. This is a low dose aspirin.
Improvements are the same with ups and downs, sometimes more stiffness and a feeling of heavy foot, sometimes less.

Very deep and relaxing sleep continues, so half of the day is very good but there is a “fall” in te afternoon. Niacin “works” much better compared to the past (the redness reaches from head to the lower parts of the foot). I stopped getting up to go to the bathroom during the night or very early in the morning.

I think changing key elements of the treatment of the protocol (such as Vitamin D, E, along with some like Curcumin, etc.) that I had to stop because of the anticoagulants had gradually a negative impact (eg in bowel function that affects everything and moving ) but seems to be temporary. From now on, I add besides Salospir:

Vitamin D 2000IU as Colecalsiferol (there are some evidence that Vitamin D plays a role in helping the blood to clot while some others say that it helps with blood clotting to legs to patients with cancer- at any case I think 2000IU is a safe and low dose while taking Salospir)

Calcium 500mg as Citrate.

No Fish Oil yet with the aspirin.

Don’t jump into conclusions because as I have said before the liberation treatment doesn’t mean direct cure for MS. The damage done to the CNS takes time to get fixed. The important thing is that a great discovery has been made and gives you the opportunity to remove a very serious cause that directly impacts you MS symptoms which in the future (sooner or later) will play a role to your therapy…Most of all, safely and with no drugs!

* 1 week after: Very deep sleep. It seems I need to sleep early at nights AND noons. Improvements in mobility have been confirmed from my wife during a trip. Faster and steadier mobility, walking without bending.

* 2 weeks after: Still deep sleep. No dizziness after swimming. Very good balance with closed eyes something I notice while I am on the shower. There are ups and downs but they do not reverse the general image.

Other things I notice without being sure if they are related to CCSVI: No signs of allergies (I had a few this time of the year which I controlled by increasing Vitamin C). Falling to my knees easier and getting up from this position. Swimming and exercising easier (stretching etc).
Despite the improvements there is still difficulty in mobility due to stiffness/heavy feeling and mild numbness. Usually feeling worse after noons.

What do I take while I am on blood thinners:
Vitamin C: 5 grams daily
Beta Carotene: 25000IU daily
Magnesium: 500mg daily
Β100: 1 daily
Pantothenic Acid 500mg daily

Probiotics
Selenium 400mcg daily
Niacin 150mg 3 times weekly to prevent blood clots
MSM(organic sulfur) 3000mg daily

Β1 - Thiamine: 400mg - 600mg daily separated in two different times of the day
Liver Extract: 1ml once weekly because it contains Vitamin K which helps the blood coagulate.
Injection Β12 from time to time

To see more about Vitamins look here:
http://www.mymultiplesclerosis.gr/index.php/suggestion_vits

To detoxify from iron I drink several types of organic Green Tea (there is a pharmaceutical form which is decaffeinated which is better). Make sure you brew it because Green tea leaves are also high in Vitamin K when they are raw. Also be careful of my nutrition to avoid eating Green leafy vegetables while I am on blood thinner (at least not eating every day and in big quantities).

Remember Vitamin E, Fish Oil, Vitamin D, Calcium should be avoided while you are on blood thinners because they also thin the blood. At any case consult your doctor. Maybe the type of anti-coagulant you take is mild and you can have 400iu of Vitamin E at the same time. < !adsensestop-->

Επέμβαση 23/06/2010:

Αριστερή σφαγίτιδα: Μεμβράνη που μπλόκαρε τη ροή στη βάση σχεδόν τελείως. Χρειάστηκε απόφραξη (σπάσιμο της μεμράνης) ενώ εντοπίστηκαν στενώσεις στη βάση και στην κορυφή. Άνοιξαν με 3 μπαλόνια. Πάνω από 90% οι στενώσεις.

Δεξιά σφαγίτιδα: 2 Μεμβράνες που μπλοκαραν τη ροή. Έσπασαν και οι δυο.

Άζυγος: Μια στένωση 99%! 1 μπαλόνι.

Αμέσως μετά την επέμβαση:Άμεση ζεστασιά, σχεδόν κάψιμο όσο περνούσε η ώρα, στα πέλματα και τις πατούσες που ανέβηκε ως ένα σημείο. Φυσιολογική αίσθηση θερμοκρασίας - όχι κρύα πόδια δηλαδή -, μείωση μουδιάσματος.

24/6/2010: Ακόμα μεγαλύτερη βελτίωση της αίσθησης όσο περνά η ώρα. Μονάχα η αίσθηση όμως, όχι κάτι φοβερό στην κίνηση.

25/62010:Μείωση σπαστικότητας/ αίσθησης βάρους, καλύτερη ισορροπία. Σχεδόν κανένα μούδιασμα το πρωί που το ένιωσα κάπως ξανά και το μεσημέρι χωρίς επίπτωση στη βελτίωσης της κίνησης.

26/5/2010:Σχεδόν κανένα μούδιασμα καθόλη την ημέρα. Η κίνηση, ίδια.

Παρενέργειες μετά την επέμβαση: Αμέσως μετά πολύ ελαφρύ αίσθημα “γδαρσίματος” και πολύ μικρού πόνου δεξιά και αριστερά από το λαιμό (περίπου όπως νιώθουμε στα πρόθυρα κρυώματος), πολύ λίγα τσιμπηματάκια στο στήθος και κατά την αναπνοή ή την κατάποση πιο αισθητά. Ελαφριά ζάλη. Όλα εντελώς φυσιολογικά και κράτησαν μερικές μέρες.

Zamboni P., 2006: The big Idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. Journal of the Royal Society of Medicine, Vol. 99, Nov. 2006, pp. 589-593.

Zamboni P. et al., 2007: Intracranial Venous Haemodynamics in multiple Sclerosis. Current Neurovascular Research, Vol. 4, No. 4, Nov. 2007, pp. 252-258

Menegatti E. and Zamboni P., 2008: Doppler Haemodynamics of cerebral Venous Return. Review Article, Current Neurovascular Research, Vol. 5, No. 4, Nov. 2008, pp. 260-265.

Zamboni P. et al., 2008: Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. Research paper, Journal of Neurology, Neurosurgery, and Psychiatry, Vol. 80, 2009, pp. 392–399. (originally published online Dec. 5th 2008)

Zamboni P. et al., 2009: The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis, Journal of the Neurological Sciences, Vol. 282, 2009. pp. 21–27

Zamboni P. et al., 2009: Venous Collateral Circulation of the Extracranial Cerebrospinal Outflow Routes. Review Article, Current Neurovascular Research, Vol. 6, No. 3, Aug. 2009, pp. 204-212

Singh and Paolo Zamboni, 2009: Anomalous venous blood flow and iron deposition in multiple sclerosis. Journal of Cerebral Blood Flow & Metabolism, Vol. 29, Sep. 2009, pp. 1867–1878 (Published online 2 September 2009)

Zamboni P. et al., 2009: Rationale and preliminary results of endovascular treatment of multiple sclerosis, the liberation procedure. In “Vascular and Endovascular Controversies Update”, Ed. R.M. Greenhalgh, ISBN: 0-9544687-6-7, pp. 71-79

Zamboni P. et al., 2009: A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency. Journal of Vascular Surgery, Vol. 50, No 6, Dec. 2009, pp. 1346-1358.

P. Zamboni, E. Menegatti, B. Weinstock-Guttman, C. Schirda, J. L. Cox, A. M Malagoni, D. Hojnacki, C. Kennedy, M. G. Dwyer, N. Bergsland, R. Galeotti, I. Bartolomei, F. Salvi, M. Ramanathan, R. Zivadinov. 2009: The severity of CCSVI in patients with MS is related to altered Cerebrospinal Fluid dynamics. Functional Neurology, Vol. 24, No. 3, pp. 133-138.