My Multiple Sclerosis

The reason we have delayed writing something about these findings despite the first very encouraging data was because we didn’t want to give the wrong impression and
because we wanted to watch all this closer with patience.
We feel that is time to say a few words since we believe that this discovery can contribute decisively to what we call “Cause of MS” and the therapy section as well.
Also throughout the evidence so far we believe certain parts of the protocol are backed up and the protocol itself is a true proof for the theory of Chronic Cerebrospinal Venous Insufficiency (CCSVI).

CCSVI is a chronic condition if left untreated, which causes blood from the brain and spine to be slowed or stopped in its attempt to flow back to the heart. Let’s see closer what is all about and what is the relation of the CCSVI with the protocol in our opinion.

1. What exactly is CCSVI?

CCSVI is a chronic (ongoing) problem where blood from the brain and spine has trouble getting back to the heart. It’s caused by stenosis (a narrowing) in the veins that drain the spine and brain. Blood takes longer to get back to the heart, and it can reflux back into the brain and spine or cause edema and leakage of red blood cells and fluids into the delicate tissue of the brain and spine. Blood that stays in the brain too long creates “slowed perfusion”…a delay in deoxyginated blood leaving the head. This can cause a lack of oxygen (hypoxia) in the brain. Plasma and iron from blood deposited in the brain tissue are also very damaging.

2. How is this related to MS?

We must say that this condition isn’t caused by MS, although initially there was such a case. It is more likely to deform into a vein that may be available even from the moment we are born. The existence of stenosis appears to be independent of MS and co-existed.
A top Italian surgeon Dr Paolo Zamboni has completed a preliminary investigation using ultrasound and MRV (magnetic resonance venography) to examine the veins which lead to the brain. The investigation involved hundreds of patients and healthy people. Dr. Zamboni discovered that the majority of the patients with multiple sclerosis including one of which happened to be his wife, had jugular and azygos veins which drain blood from the brain distorted or blocked. In the healthy controls without multiple sclerosis, the veins or vessels were not.
Since the original study, two further studies have been completed to backup the theory. The first, an open label study by Dr Zamboni himself (view here) followed MS Patients after treatment. The second a randomised initial clinical study, found that 55% of MS patients had vein abnormalities (view details).
Epidemiological studies conducted by research groups in the United States and Europe have confirmed that there is a correlation between the two diseases at least 90% of cases. This relationship is actually stable and significant.

3. What is the theory behind this?

Dr. Zamboni theorises that CCSVI causes a build up of iron in the brain and causes damage to important blood vessels. The damage allows metals and other unwelcome cells such as immune cells, to cross the crucial blood brain barrier. This important barrier keeps blood and cerebrospinal fluid divided. Dr. Zamboni believes that the damage caused in CCSVI allows immune cells to cross the blood brain barrier leading to destruction of myelin, which is a crucial sheathing coating human nerves.

4. How can CCSVI be diagnosed?

A technique called Doppler ultrasound can tell if a patient has reflux. However the use of dopplers are very dependent on operators skill, and as a result often give false results. The doppler of the neck is not enough. It needs to be combined with a “transcranial doppler” to show reflux into the brain.
Being tested for CCSVI requires tests conducted by a doctor who specializes in radiology. This is a field of medicine which specialises in seeing inside the veins, often called a venography. Dye is injected into a humans veins to see how blood is flowing in the patients body.

Dr. Zamboni has a very specific protocol for doppler scanning of the jugular veins. This can be downloaded here.

5. Can CCSVI be cured?

Yes. With the method called invasive phlebography. The findings of the ultrasound Doppler method in the jugular vein are confirmed and then using the angioplasty balloon in opening up the vein. A catheter is inserted into the vein and inflates a balloon that expands the narrowing.
It does not require hospitalization, surgery or general anesthesia and is painless procedure. It may last from one to several hours.

6. Is there a probability of restenosis?

Yes. So after surgery there are usually rather frequent exams. If this happens, you could follow new angioplasty procedures without any problems. It is said that if the problem is found in azygous then the chances of restenosis are greatly reduced.
The use of stends jas been suggested but due to the dangers there are it is much better to be avoided.

7. Does the treatment of CCSVI influence the course of multiple sclerosis?

Yes. It appears that improved venous circulation to the brain reduces the number of relapses and active outbreaks and improves symptoms, the quality of life. In patients with worsening multiple sclerosis, deterioration can be stopped or slowed down. There are spectacular results in symptoms that vary depending on the case.

8. How the CCSVI is related with Dr Klenner’s the protocol?

The protocol includes vitamins that directly help the restoration or improve the blood flow in the body. First and best vitamin that is used for this cause is niacin (Vitamin B3). Niacin creates an instant flush and many patients reported an immediate improvement of their situation during the flush. Niacin is a vasodilator, opens all blood vessels and capillaries to allow maximum blood flow.
Vitamin C, E and Fish Oil also play an important role. Among other things Vitamin E and Fish Oil help the better blood flow while Vitamin C helps the vein health.

The body needs vitamin C to produce two major materials: collagen and elastin. Both are used for the repair and maintenance of the veins in order to be kept strong and flexible. Even more important for maintaining the health of veins and capillaries are bioflavonoids. The chemical compounds are often found in the same foods as vitamin C and identified as it’s metabolites.

Finally, all antioxidants used in the protocol are useful because of the iron oxidation, caused by CCSVI.

9. Should we stop the protocol right after the operation?

Usually after the surgery blood thinners are administered to eliminate the chance of thrombosis. YOU SHOULDN’T TAKE VITAMIN E OR FISH OIL WHILE USING THE BLOOD THINNERS. According to patients who asked their doctors about the protocol and had the “Liberation” procedure, there is no danger having the protocol right after and that is what they did without problems. Asking the question if Liver Extract may cause side effects because of the iron contained the answer was negative.
At any case inform your doctor.

Don’t forget that MS is a multifactorial disease and CCSVI is not the solution. Correction of the CCSVI doesn’t mean a complete cure, even if there’s many times an amazing improvement of many symptoms. A simple opening of the veins, eventhough is very – very important and needed, can not undo the damage caused in the Central Nervous System alone. The factors interfering with MS and are described in this website will continue to exist and they may affect you in a negative way. Thus generally the protocol should be continued.

More information about this issue we hope to be available soon. It would certainly be a good question how the protocol is helps with the CCSVI theory. Maybe you could ask your doctor and give us a good feedback.

10. Is there a special thing to do after the operation?

Besides of the blood thinners given, there is nothing more. Follow your doctor’s advice.

Εδώ και καιρό μια νέα και πολλά υποσχόμενη ανακάλυψη έγινε από τον Ιταλό αγγειολόγο γιατρό Dr Zamboni, που σχετίζεται με τη ΣΚΠ. Λέγεται Χρόνια Εγκεφαλονωτιαία Φλεβική Ανεπάρκεια (ΧΕΝΦΑ). Ας δούμε πρώτα περί τίνος πρόκειται, τι σχέση μπορεί κατά τη γνώμη μας να έχει με το πρωτόκολλο του Dr Klenner.

Ο λόγος που καθυστερήσαμε, παρόλες τις πρώτες ενθαρρυντικές ενδείξεις, να ενημερώσουμε ήταν επειδή δεν θέλαμε αφενός να δημιουργήσουμε λάθος εντυπώσεις και αφετέρου θέλαμε να παρακολουθήσουμε λίγο περισσότερο το θέμα. Αισθανόμαστε πως ήρθε η ώρα να πούμε δυο λόγια μιας και θεωρούμε πως η ανακάλυψη αυτή μπορεί να συμβάλλει σε μεγάλο βαθμό σε αυτό που λέμε «Εξάλειψη των αιτιών της ΣΚΠ» αλλά και στον τομέα της θεραπείας όπως δείχνει η μέχρι τώρα εμπειρία. Επίσης μέσα από τα μέχρι τώρα δεδομένα ενισχύονται ουσιαστικά και με επιστημονικό τρόπο πλευρές του πρωτοκόλλου.

Ας δούμε πρώτα μερικά ερωτήματα με τις απαντήσεις τους:

1.Tί είναι η ΧΕΝΦΑ;

Η Χρόνια Εγκεφαλονωτιαία Φλεβική Ανεπάρκεια είναι ένα χρόνιο και εξελίξιμο, πρόβλημα όπου το αίμα έχει πρόβλημα να επιστρέψει στην καρδιά από τον εγκέφαλο και τη σπονδυλική στήλη. Προκαλείται από στένωση στις φλέβες που διατρέχουν τη σπονδυλική στήλη και τον εγκέφαλο. Συνήθως, συμβαίνει στις φλέβες που ονομάζονται σφαγγίτιδες και/ή άζυγος.
Λόγω αυτού του προβλήματος, χρειάζεται περισσότερος χρόνος για να επιστρέψει το αίμα στην καρδιά, και μπορεί να παλινδρομήσει πίσω στον εγκέφαλο και τη σπονδυλική στήλη. Προκαλείται οίδημα και διαρροή των ερυθρών αιμοσφαιρίων και υγρών στο λεπτό ιστό του εγκεφάλου και της σπονδυλικής στήλης. Το αίμα που παραμένει στον εγκέφαλο πολύ καιρό δημιουργεί “επιβραδυντική αιμάτωση”. Αυτό μπορεί να προκαλέσει έλλειψη οξυγόνου (υποξία) στον εγκέφαλο γεγονός που έχει συνδεθεί με το σύμπτωμα της αδυναμίας στη ΣΚΠ. Το πλάσμα και ο σίδηρος από το αίμα που αποθηκεύεται στον εγκεφαλικό ιστό είναι επίσης εξαιρετικά επιζήμιες.

Εν ολίγοις η ΧΕΝΦΑ είναι μια κατάσταση όπου η ροή του μη-οξυγονομένου αίματος από τις φλέβες που περιβάλλουν τον εγκέφαλο και τη σπονδυλική στήλη επιβραδύνεται ή διακόπτεται στο να επιστρέφει στην καρδιά.

2. Πως σχετίζεται αυτό με τη ΣΚΠ;

Πρέπει να πούμε ότι αυτό μάλλον δεν προκαλείται λόγω της ΣΚΠ αν και αρχικά υπήρξε μια τέτοια υπόθεση. Είναι πιθανότερο να πρόκειται για δυσμορφία στη φλέβα που ενδέχεται να υπάρχει ακόμα και από τη στιγμή που γεννιόμαστε. Επομένως, η ύπαρξη στένωσης, φαίνεται να είναι ανεξάρτητη από τη ΣΚΠ και να προϋπάρχει αυτής.
Ένας κορυφαίο Ιταλός χειρούργος ο Dr Paolo Zamboni ολοκλήρωσε μια προκαταρκτική έρευνα χρησιμοποιώντας υπέρηχους και MRV (magnetic resonance venography) για να εξετάσει τις φλέβες που οδηγούν στον εγκέφαλο σε εκατοντάδες ασθενείς και υγιείς. Ο Dr Zamboni ανακάλυψε οτι η πλειοψηφία των ασθενών με ΣΚΠ συμπεριλαμβανομένης και τη ίδιας του της γυναίκας, είχαν αλειωμένες ή παραμορφωμένες φλέβες (σφαγγίτιδες και άζυγος). Στους υγιείς ανθρώπους του δείγματος οι φλέβες δεν είχαν κανένα πρόβλημα.
Από τότε, άλλες δυο έρευνες έχουν διεξαγχθεί και επιβεβαιώνουν τη θεωρία. Η πρώτη, ανοιχτή μελέτη από τον Dr Zamboni, αφορούσε ασθενείς με ΣΚΠ και η δεύτερη σε τυχαιοποιημένη κλινική μελέτη αποκαλύφθηκε ένα 55% ασθενών με ΣΚΠ με διάφορες φλεβικές ανωμαλίες.

3. Σε πόσες περιπτώσεις πολλαπλής σκλήρυνσης υπάρχει και ΧΕΝΦΑ;

Eπιδημιολογικές μελέτες που πραγματοποιούνται από τις ερευνητικές ομάδες στις Ηνωμένες Πολιτείες και την Ευρώπη έχουν επιβεβαιώσει ότι υπάρχει μια συσχέτιση μεταξύ των δύο ασθενειών τουλάχιστον στο 90% των περιπτώσεων. Αυτή η συσχέτιση είναι πράγματι σταθερή και σημαντική.

4. Πώς εντοπίζεται η ΧΕΝΦΑ;

Η ΧΕΝΦΑ μπορεί να εντοπιστεί με τη βοήθεια μιας μη επεμβατικής τεχνικής αποκαλούμενης echo-Doppler (υπερηχογράφημα Doppler). Με τη μέθοδο αυτή εξετάζεται αν είναι φυσιολογική η ροή του αίματος στη σφαγίτιδες και εξαρτάται πάρα ολύ από την ικανότητα του εξεταστή.
Η μέθοδος της μαγνητική φλεβογραφίας δεν θεωρείτε αξιόπιστη και ακόμα και αν δεν δείξει κάποιο πρόβλημα πρέπει να γίνεται και το υπερηχογράφημα Doppler. Φυσικά κανείς πρέπει να ξεκινάει από το τελευταίο σε κάθε περίπτωση.
Παίζει μεγάλο ρόλο και η εμπειρία του γιατρού γιατί είναι δυνατόν ενώ υπάρχει πρόβλημα, να μην υπάρχει κάτι ακόμα και το υπερηχογράφημα Doppler. Οπότε ψάξτε το μέχρι τέλους!
Ο Dr Zamboni διαθέτει ένα πολύ συγκεκριμένο πρωτόκολλο για την εξέταση Doppler στη σφαγίτιδα φλέβα και μπορείτε να το κατεβάσετε εδώ.

5. Μπορεί να θεραπευτεί η ΧΕΝΦΑ;

Γίνεται επέμβαση με «μπαλονάκι». Με τη μέθοδο που ονομάζεται επεμβατική φλεβογραφία, επιβεβαιώνονται τα ευρήματα του υπερήχου μεθόδου Doppler σφαγίτιδας φλέβας και στη συνέχεια με τη μέθοδο της αγγειοπλαστικής με μπαλονάκι διανοίγεται η φλέβα. Συγκεκριμένα, χρησιμοποιείται καθετήρας, που καθοδηγείται από τον ακτινολόγο εισάγεται στις φλέβες του ασθενή περνώντας μέσα από μια οπή που γίνεται στη φλέβα. Όταν εντοπίζονται παρεμποδίσεις φλεβών, ο καθετήρας διογκώνει ένα μπαλόνι που διαστέλλει τα στενέματα.
Δεν απαιτεί εισαγωγή στο νοσοκομείο, χειρουργείο ή γενική αναισθησία και είναι ανώδυνη διαδικασία. Μπορεί ανάλογα με την περίπτωση να διαρκέσει από 1 εώς μερικές ώρες.

6. Υπάρχει πιθανότητα επαναστένωσης;
Ναι. Γι’αυτό και μετά την επέμβαση γίνονται συχνές εξετάσεις. Σε περίπτωση που αυτό συμβεί μπορεί να ακολουθήσουν νέες επεμβάσεις χωρίς πρόβλημα. Επίσης αν το πρόβλημα είναι στην άζυγο, τότε μειώνονται πολύ οι πιθανότητες για επαναστένωση.
Η χρήση stends έχει προταθεί όμως λόγω της επικινδυνότητάς της πρέπει να αποφεύγεται.

7. Η θεραπεία της ΧΕΝΦΑ επηρεάζει την πορεία της πολλαπλής σκλήρυνσης;

Ναι. Φαίνεται ότι η βελτιωμένη φλεβική κυκλοφορία στον εγκέφαλο μειώνει τον αριθμό υποτροπών και ενεργών εστιών και βελτιώνει τη ποιότητα ζωής. Στους ασθενείς με επιδεινούμενη πολλαπλή σκλήρυνση, η επιδείνωση μπορεί να σταματήσει ή να επιβραδυνθεί. Υπάρχουν θεαματικά αποτελέσματα σε συμπτώματα, που ποικίλλουν ανάλογα με την περίπτωση.

8. Ποια η σχέση της ΧΕΝΦΑ με το πρωτόκολλο του Dr Klenner;

Στο πρωτόκολλο περιλαμβάνονται καταπόσιμες βιταμίνες οι οποίες έχουν άμεση ή έμμεση σχέση με την αποκατάσταση ή βελτίωση της αιματικής ροής στον οργανισμό. Πρώτη και καλύτερη βιταμίνη που χρησιμοποιείται στη θεραπεία είναι η Νιασίνη (Βιταμίνη Β3). Η Νιασίνη δημιουργεί υπεραιμία για κάποιο διάστημα και πολλοί ασθενείς δηλώνουν μια άμεση βελτίωση της κατάστασης τους για όσο διαρκεί. Η βελτίωση της αιμάτωσης σε περιοχές βλάβης από τη ΣΚΠ, βοηθά στο να μεταφέρονται σε τριχοειδή αγγεία και σημεία με πρόβλημα τα θρεπτικά συστατικά που μεταφέρονται μέσω του αίματος.
Σημαντικό επίσης ρόλο παίζει η Βιταμίνη Ε και το Fish Oil τα οποία εκτός των άλλων βοηθούν στην στη βελτίωση της αιματικής ροής.
Τέλος σημαντικό ρόλο για την προστασία των φλεβών αλλά και ενάντια στην οξείδωση παίζει η βιταμίνη C.

Το σώμα χρειάζεται τη βιταμίνη C για να κατασκευάζει δύο σημαντικούς συνδετικούς ιστούς: κολλαγόνου και ελαστίνης. Και οι δύο αυτές ουσίες χρησιμοποιούνται για την επισκευή και συντήρηση ώστε να κρατιέται ισχυρή και ευέλικτη η φλέβα. Ακόμη πιο σημαντική για τη διατήρηση της υγείας των φλεβών και των τριχοειδών αγγείων είναι τα βιοφλανοειδή. Οι χημικές ενώσεις που βρίσκονται συχνά στην ίδια τρόφιμα όπως βιταμίνη C και χαρακτηρίζονται ως μεταβολίτες της.
Τέλος όλα τα αντιοξειδωτικά είναι χρήσιμα λόγω της οξείδωσης λόγω παραγωγής σιδήρου, που προκαλείται στον οργανισμό όταν υπάρχει πρόβλημα στένωσης σε κάποια φλέβα σύμφωνα με τη ΧΕΝΦΑ.

9. Πρέπει να σταματήσω το πρωτόκολλο όταν κάνω την επέμβαση ;

ΣΥΝΗΘΩΣ, ΕΠΕΙΔΗ ΜΕΤΑ ΤΗΝ ΕΠΕΜΒΑΣΗ ΧΟΡΗΓΟΥΝΤΑΙ ΑΝΤΙΘΡΟΜΒΩΤΙΚΑ ΔΕΝ ΠΡΕΠΕΙ ΝΑ ΓΙΝΕΤΑΙ ΧΡΗΣΗ ΒΙΤΑΜΙΝΗΣ Ε ΚΑΙ FISH OIL. Σύμφωνα με ασθενείς που εφαρμόζουν το πρωτόκολλο, που εφάρμοσαν τη θεραπεία για ΧΕΝΦΑ και ρώτησαν το γιατρό τους δεν υπάρχει κίνδυνος και το συνέχισαν χωρίς προβλήματα.
Στην ερώτηση σε γιατρό αν υπάρχει πρόβλημα με τη χρήση Liver Extract λόγω του σιδήρου που περιέχει η απάντηση ήταν αρνητική. Επομένως ως τώρα εκτός της Βιταμίνης Ε και του Fish Oil κατά τη χρήση αντιθρομβωτικών το πρωτόκολλο μπορεί να συνεχιστεί μετά την επέμβαση. Σε κάθε περίπτωση βέβαια να ενημερώσετε το γιατρό σας.

Περισσότερες πληροφορίες ελπίζουμε να είναι διαθέσιμες σύντομα αφού το πως συνδυάζεται το πρωτόκολλο με τη θεραπεία της ΧΕΝΦΑ αποκτά εξαιρετικό ενδιαφέρον.
Ενημερώστε μας για όποια επιπλέον πληροφορία.

9. Υπάρχει κάτι άλλο που καλό είναι να κάνω μετά την επέμβαση;

Έκτός από τα αντιθρομβωτικά που χορηγούνται δεν γνωρίζουμε κάτι άλλο. Ενημερωθείτε από το γιατρό σας.

Orthomolecular Medicine News Service, December 15, 2009
 

PUTTING THE "C" IN CURE:
Quantity and Frequency are the Keys to Ascorbate Therapy

Comment by Andrew W. Saul
Editor-In-Chief, Orthomolecular Medicine News Service

(OMNS, December 15, 2009) What is it about a little left-handed molecule of six carbons, six oxygens, and eight hydrogens that ticks off so many in the medical community? Maybe it's cases like this one: Ray, a health professional I know, had an 11-month old son who was very sick for over a week. No one, and I mean no one, in their family had had any sleep in a long time. They were up night after night with this child, who had a high fever, glazed watery eyes, tons of thick watery mucus and labored breathing. The child would not sleep, and did little else but cry. The baby was under the care of a pediatrician, who, in the infant's eleven months on earth, had already prescribed twelve rounds of some very serious antibiotics. That they clearly were not working was all too apparent to Ray, who out of desperation decided to try something he previously had been taught to not try: bowel tolerance quantities of oral ascorbate. Ray and his wife gave their baby vitamin C about every 15 minutes. As a result, the baby was noticeably improved in a matter of hours, and slept through the night. With frequent doses continuing, the child was completely well in less than 48 hours. Ray calculated that the child had received just over 2,000 mg vitamin C per kilogram body weight per day. This is even more than what vitamin C expert Dr. Frederick Robert Klenner customarily ordered for sick patients. Remarkably, at 20,000 milligrams of vitamin C/day, that baby never had bowel-tolerance loose stools. (1)

With such a little body, you have to marvel at where all that ascorbate was going. Of course, it is the opinion of those who promulgate the US RDA and related nutritional mythology that almost all of that baby's vitamin C went uselessly into the toilet. Ray and his wife would tell you differently. They would say that their sick child soaked it up like a sponge, and then promptly got better. You choose the answer that works for you.

Quantity of Dose

Dr. Frederick Robert Klenner earned his MD from Duke University School of Medicine and was subsequently board certified in diseases of the chest. (2) A working summation of Dr. Klenner's therapeutic use of vitamin C is 350 milligrams vitamin C per kilogram body weight per day (350 mg/kg/day), in divided doses. (3) Since a kilogram is about 2.2 pounds, this translates to:

 

mg of Vitamin "C"	Body Weight	Number of Doses	Amount per dose
35,000 mg	220 lb	17-18	2,000 mg
18,000 mg	110 lb	18	1,000 mg
9,000 mg	55 lb	18	500 mg
4,500 mg	28 lb	9	500 mg
2,300 mg	14-15 lb	9	250 mg
1,200 mg	7-8 lb	9	130 - 135 mg

Although these quantities may seem high, Dr. Klenner actually used as much as four times as much for serious viral illness, administered by injection. The oral doses listed above are, for the doctor, comparatively moderate.

Frequency of Dose

For those unable to obtain intravenous vitamin C, it is essential to pay special attention to one of the most important aspects of vitamin C therapy: dividing the dosage improves absorption and retention of vitamin C. High oral doses of vitamin C yield higher blood levels of the vitamin, and dividing the oral doses maintains those higher levels. Although initially seeming almost too obvious to mention, these are not self-evident concepts. Many a medical website and government-based dietary recommendation hinge on ignoring them. Hilary Roberts, PhD, writes: "Stressed and even mildly ill people can tolerate 1,000 times more vitamin C, implying a change in biochemistry that was ignored in creating the RDA. In setting the RDA, unsubstantiated risks of taking too much vitamin C have been accorded great importance, whereas the risks of not taking enough have been ignored. Real scientists understand that 'no scientific proof' is a fancy way of saying 'we don't like this idea.'" (4)

And there is ample proof to not like. Vitamin C, in very high doses, has been used to successfully treat several dozen illness (5), with a published, peer-reviewed literature spanning the last 60 years. Therefore, the effectiveness and safety of megadose vitamin C therapy should, by now, be yesterday's news. Yet I never cease to be amazed at the number of persons who remain unaware that vitamin C is the best broad-spectrum antibiotic, antihistamine, antitoxic and antiviral substance there is. Equally surprising is the ease with which some people, most of the medical profession, and virtually all of the media have been convinced that, somehow, vitamin C is not only ineffective but is also downright dangerous.

Bias against Ascorbate Therapy

When you pick up a health or nutrition book and need to know really fast if it is any good or not, just check the index for "Klenner" and three other key names: Cathcart, Stone, and Pauling. Robert F. Cathcart, an orthopedic surgeon, administered huge doses of vitamin C to tens of thousands of patients for decades (6), without generating a single kidney stone. Irwin Stone, the biochemist who first put Linus Pauling onto vitamin C, is the author of The Healing Factor: Vitamin C against Disease. (7) Pauling cites Stone thirteen times in his landmark book How to Live Longer and Feel Better (8), a recommendation if there ever was one. The importance of vitamin C's power against infectious and chronic disease is extraordinary. To me, omitting it is tantamount to deleting Shakespeare from an English Lit course.

Because of such bias, the primary way patients (and through them, their physicians) have been exposed to Dr. Klenner's work has been through Dr. Lendon Smith's 68-page Clinical Guide to the Use of Vitamin C: The Clinical Experiences of Frederick R. Klenner, M.D. (9) Upon discovering this book, one of my undergraduates submitted a paper to another class discussing a substantial number of medical references she had found on vitamin C as a cure for polio. That course's instructor told me privately that the student's work was absurd, and he literally described her as a "dial tone." I recall a nutritional presentation I made to a hospital staff. All was going well until I mentioned using vitamin C as an antibiotic, as Dr. Klenner did. The mood changed quickly. And how many of us have heard this old saw: "If vitamin C was so good, every doctor would be prescribing it!"

Cardiologist Thomas Levy, MD, explains: "I could find no mainstream medical researcher who has performed any clinical studies on any infectious disease with vitamin C doses that approached those used by Klenner. Using a small enough dose of any therapeutic agent will demonstrate little or no effect on an infection or disease process." (10)

Preventive Doses

Dr. Klenner recommended daily preventive doses of 10,000 to 15,000 mg/day. He advised parents to give their children their age in vitamin C grams (1 g = 1,000 mg). That would be 2,000 mg/day for a two year old, 9,000 mg/day for a nine year old, and for older children, a leveling-off at about 10,000 mg/day. As for me, I simply say, "Take enough C to be symptom free, whatever that amount may be." It worked for my family. I raised my children all the way into college and they never had a dose of any antibiotic. Not once.

It is high time for medical professionals to welcome vitamin C megadoses and their power to cure the sick. Cure is by far the best word there is in medicine. It would seem that you cannot spell "cure" without "C." I do not think Dr. Klenner would dispute that.

(Andrew W. Saul taught nutrition, health science and cell biology at the college level, and has won three New York State teacher fellowships. He is the author of Doctor Yourself and Fire Your Doctor! and, with Dr. Abram Hoffer, co-author of Orthomolecular Medicine for Everyone and The Vitamin Cure for Alcoholism. Saul is featured in the documentary film Food Matters.)

References:

(1) Bowel tolerance as an indicator of vitamin C saturation is discussed by Dr. RF Cathcart at http://www.doctoryourself.com/titration.html and http://www.doctoryourself.com/cathcart_thirdface.html

(2) For more about Dr. Klenner's life and work: http://www.doctoryourself.com/klennerbio.html

(3) Klenner FR. The significance of high daily intake of ascorbic acid in preventive medicine, p 51-59, in: A Physician's Handbook on Orthomolecular Medicine, Third Edition, Roger Williams, PhD, ed. Keats, 1979.

(4) Hickey S and Roberts H. Ascorbate: The science of vitamin C. 2004. ISBN 1-4116-0724-4. Morrisville, NC: Lulu.

(5) http://www.doctoryourself.com/vitaminc.html

(6) http://www.doctoryourself.com/biblio_cathcart.html

(7) The complete text of Irwin Stone's book The Healing Factor is posted for free reading at http://vitamincfoundation.org/stone/

(8) Pauling L. How to Live Longer and Feel Better, revised edition, 2006. ISBN-13: 9780870710964. Reviewed at http://www.doctoryourself.com/livelonger.html

(9) The full text of Dr. Frederick R. Klenner's Clinical Guide to the Use of Vitamin C is posted for free reading at http://www.seanet.com/~alexs/ascorbate/198x/smith-lh-

clinical_guide_1988.htm

(10) Levy TE. Vitamin C, Infectious Diseases, and Toxins: Curing the Incurable. Livon Books, 2002. ISBN: 1-4010-6963-0 and 978-1401069636

Nutritional Medicine is Orthomolecular Medicine

Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.

Editorial Review Board:

Carolyn Dean, M.D., N.D.
Damien Downing, M.D.
Michael Gonzalez, D.Sc., Ph.D.
Steve Hickey, Ph.D.
James A. Jackson, PhD
Bo H. Jonsson, MD, Ph.D
Thomas Levy, M.D., J.D.
Jorge R. Miranda-Massari, Pharm.D.
Erik Paterson, M.D.
Gert E. Shuitemaker, Ph.D.

Andrew W. Saul, Ph.D., Editor and contact person. Email: omns@orthomolecular.org

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The truth is that it has not been precisely justified how the combination of the constituents of the protocol works for MS. Scientific research, profit-oriented, CRAB – centered and guided, is not able and above all it doesn’t aim at providing reasonable responses. Nevertheless, one can make several hypotheses about each suggested constituent by analyzing its properties and draw secure conclusions based on scientific research.

Fish Oil has known anti inflammation effects in blood and tissues. Also the lack of Vitamin D , as it becomes obvious through a series of studies, plays a more and more important role to the incidence of MS due to the role it plays in the development of the person from very young ages. Vitamins C, E play a very important role against the generation of free radicals. Oxidation always affects MS’ers much more than healthier people. Relevant examples, positive for human health, are found for every constituent of the protocol and especially for the Central Nervous or the myoskeletal System which are crucial for neurological disorders or the myoskeletal (see B 100 Tablet, B12 - methylcobalamine, Calcium - Magnesium etc).

 Additionally to the above, there is a very important field the protocol contributes to, being decisive for MS patients due to their vulnerability in the Central Nervous System: heavy metals excretion. MS patients have a sensitive CNS with all its consequences. The progress of the disease usually causes problems in bowel function (constipation, diarrhea) that is a main detoxification means. This flaw makes them more vulnerable to a series of dangers in comparison to healthier people, such as heavy metals, a subject under discussion in this article.

DANGERS IN THE MARKET

The procedure of heavy metals excretion is generally called chelation.

There is a variety of products or kits in the market and several suggestions on this procedure but we‘ve better not to trust them if we are not perfectly sure. It is suggested that in any case you should consult a  knowledgeable physician about this subject; this is why we will not try to describe or suggest such products. The reason for our being so cautious is that this procedure may become dangerous, especially to constipated patients.

In order for the heavy metals to leave the body they first have to detach from the healthy tissues and organs they are stuck on, followingly they bind with substances helping their passing to the intestine and finally they are expelled. The excretion of heavy metals through the intestine is the main kind of detoxification from heavy metals. An important organ of detoxification is the skin through sweating. It becomes obvious that accumulation of toxins in the intestine after a successful chelation may cause more serious problems in case they are not fully excreted from the body.

Another reason is that the methods are numerous and there is not one single way for all patients. Many strong substances are used for this purpose and it is only under the supervision of a specialist that one should use them and NEVER TRY IT ALONE.

Finally, there is always the danger to overload the body if many different substances are taken besides the protocol without medical suggestion and supervision.

For the above cited reasons we will discuss only the substances suggested in the protocol and some other natural – vegetable very mild choices one can incorporate in everyday life and have very good results without danger.

  FREE RADICALS AND HEAVY METALS

When free radicals come in touch with one of these tinny pieces of toxic metals, not only one new free radical is generated but a chain of millions of free radicals.

Free radicals exist in all persons, heavy metals as well. They move around several points and organs and somewhere on their way they meet again a new tinny piece of toxic metal generating new free radicals in a minute and so on.

Thus we should try to:

1. Find ways to reduce as much as possible the generation of new millions of free radicals generated in our body by the binding of metals and free radicals through chain reactions (Vitamin C, E and other antioxidants mentioned below help to that)
2. Prevent these free radicals from coming in touch with the heavy metals in our bodies in the first place.

CHELATION THROUGH THE PROTOCOL

One important contribution of the protocol is that it helps fight heavy metals, whose toxicity alone is known that it can cause symptoms similar to the ones of MS. On the other hand you know from this site that heavy metals is one of the main factors of MS.

Tips that help:

Try to consume proteins all the time, mainly animal (excpet pork which is very fatty) but vegetarian as well (eg sea algaue) according to the protocol. Protein amino-acids contain sulphur that highly facilitates the detoxification procedure. Avoid any proteinic supplement of unreliable origin.

Try to maintain 2 to 3 bowel movements per day. If there is a constipation problem read here. Remember that 90% of the mercury (a heavy metal known to be one of the most toxic ones) is expelled in our stools.

Don’t miss your daily injection of Thiamine (Β1)(1): Thiamine, being a main injectable vitamin in the protocol, has been found to play an important role in the confrontation of heavy metals (arsenic, lead, mercury etc). Especially mercury and lead compete with Thiamine absorbing the Sulphur contained in it. Sulphur is known to act as a magnet for heavy metals.

Riboflavine (vitamin Β2 contained in Β100): Also contains sulphur.

Vitamin Β6 (Pyridoxine – contained in Β100): Necessary to the metabolic procedure that transforms methionine into cysteine and followingly to glutathione (amino-acid transformed into strong anioxidative means).

Magnesium: Metals such as Magnesium are necessary to the optimal functioning of our immune system, as much as to hundreds of enzymic systems of prime importance for human health. In this way foods are more easily absorbed without irritating the digestive track that plays a crucial role to heavy metals excretion.

Take your axntioxidants every day: All antioxidants in the protocol (Vitamin C(2), E, Beta Carotene-Vitamin Α, Selenium(3)) including Thiamine, play an irreplaceable role to the fight against new free radicals being multiplied in the presence of heavy metals.

Drink alkaline water.

Exercise according to your condition, but do it systematically and under supervision. Sweating is a good way to excrete toxins and the skin is one of the main detoxification organs.

For additional help you should know that:

There are lots of other substances and ways to fight heavy metal accumulation or at least they claim to do so. As cited above, the protocol itself caters for that purpose. Nevertheless, if you think that you need more help, here are some more very mild ways:

You can take Chlorella. Chlorella is a species of algae that helps remove toxic metals from the connective tissue of our body. It contains high levels of chlorophyll which is one of the most pure and strong foods on earth. One cannot take excessive amount of Chlorella. Check your dose by trials, starting from a low dose and increasing gradually every 2-3 days.

Include garlic in your regiment if you are not allergic or intolerant to it, not in supplement form but in fresh natural form. In this way you enhance the Sulphur reserves of your body. 2-3 cloves per day for as long as your program lasts sound like a good idea. Crush the cloves so as to set their active ingredients free.

Start taking MSM (4). MSM is a kind of Sulphur acting on the membranes of the cells and thus helping your body to get rid of mercury.

Start using coriander (5). Coriander will contribute to the movement of mercury from the tissues, so as Chlorella will be able to bind with it and guide it out of the body through bowel movements. Coriander is found in most health food stores, super markets or shops selling spices. You can also add it to vegetable juices (being an excellent source of metals such as Calcium and Magnesium). Coriander alone is not enough to totally remove heavy metals from the body.

During your heavy metal detoxification, make sure that you take your daily vitamins and basic metals such as Calcium and Magnesium.

(1)Lead and mercury are strongly anti thiamine, binding to the sulphur entity in thiamine.
Heavy metal poisoning is typically characterized by symptoms common with thiamine deficiency since metals, such as arsenic or lead, block a crucial metabolic step converting thiamine to its coenzyme form. Omar Alvarado, Thomas J. Fellers and Michael W. Davidson

 

Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in rats

(2) Vitamin C protects against Heavy Metal Poisoning and reduces behaviour disorders Orthomolecular Medicine News Service, October 8, 2007

Effects of ascorbic acid deficiency on methyl mercury dicyandiamide toxicosis in guinea pigs \

Yamini B, Sleight SD.

(3) Selenium in the treatment of heavy metal poisoning and chemical carcinogenesis by

Whanger PD.

(4)The Miracle of MSM The Natural Solution for Pain

Jacob, S., Lawrence, RM, Zucker, M. Penguin Putnam, New York, NY 1999.

(5)Prophylactic Efficacy of Coriandrum sativum (Coriander) on Testis of Lead-Exposed Mice.

 

Sharma V, Kansal L, Sharma A.

 

Removal and preconcentration of inorganic and methyl mercury from aqueous media using a sorbent prepared from the plant Coriandrum sativum.

 

Karunasagar D, Krishna MV, Rao SV, Arunachalam J.

 

My name is Chip Presendofer and I’m writing to ask for your help.

A friend of mine, Bill Gordon, has a sister with MS. I mentioned the Klenner protocol and told him my wife started on it in August of this year and within two weeks she was sleeping soundly through the night. He asked me to tell his sister about it and then he suggested we create a phone support line for people who would like to hear about it and didn’t have computer access.

Our initial call is scheduled for Wednesday, November 18^th at 7:00 PM EST and the phone number is 011-1-712-432-0111. Just call that number and input the following PIN when prompted: 160083# for access to the call.

Would you please answer the following questions anonymously so that I can read some of them on the call as a way to let others know how the protocol has affected other MS patients? You can send your answers to our email address at: mssupportline[at]gmail[dot]com or you can fax them directly to me at 011-1-215-886-1203 or you can phone me, toll free in the US, at 1-888-442-2322 and read them to me.

1. How long have you had MS?

2. How old are you now?

3. How old when diagnosed with MS?

4. How did you learn about the Klenner protocol?

5. How long have you been on the protocol?

6. Are you fully applying the protocol including all oral vitamins and daily injections?

7. Do you apply any other therapies simultaneously with the protocol or take any medicine other than protocol suggestion? If yes, why?

8. Any hesitations about starting the protocol? If yes, what were they? Why?

9. What was your condition prior to Klenner? Were you able to walk at all or were you completely wheelchair bound?

10. What is your condition now?

11. What is your experience with the protocol?

12. Any misgivings about the protocol? If yes, what are they?

13. Did you have difficulty finding a doctor to prescribe the materials? How did you find the doctor?

14. What other medications had you been on?

15. What is your diet? How important is diet?

16. Anything else you would like to say?

 

The goal is to provide accurate information to people and encourage them to take control of their own health and make decisions based upon reliable information from others who have been in the same situation.

 

This support line is about offering hope to people who have been told their situation is hopeless.

Thank you for considering this request.

Chip Presendofer

1011 Church Road

Oreland, PA 19075

mssupportline@gmail.com